Abstract: The stability of rock slope under the effect of blasting excavation is so important to be solved urgently. After the blasting test on the actual project, the propagation rule of blasting wave is obtained, which can take the elevation effect into account. Using the quasi-static method to calculate the inertia force of blasting. The integral method is put forward to analyze the dynamic stability of slope under the effect of blasting vibration for the first time. Besides, it searched the most dangerous sliding surface and gained the minimum safety factor through the program of MATLAB. This method is proved to be one of the most valid methods to study the dynamic stability of slope through the sample.