Abstract: This paper takes a fill slope in Chongqing for example,uniform design method is adopted to arrange experiment,regression analysis is used to compare and analyze the differences that each factor influences on the stability of slope.The sensitivity of every influencing factor is obtained.The main factors affecting the slope stability are internal friction angle of filler φ,slope gradient α and the groundwater level H_w.Based on the sensitivity of influencing factors,more pertinence engineering measures will be taken to the design and construction of fill slope.