Abstract: Taking the construction project of Pediatric Comprehensive Building of Shandong Provincial Hospital as an example, the key technology in the design of deep foundation pit and the key control points in the construction process are discussed. The depth of the foundation pit is 15.7~19.9 m, and the surrounding conditions are complex. The newly built pediatric complex is only 3.2 m away from the 6-story pediatric ward building on the east side. Considering the site stratum and surrounding environment, pile-anchor structure is adopted in this foundation pit. The scheme of high-pressure jet grouting pile waterproof curtain combined with tube well dewatering is adopted in groundwater control. During the whole construction of the project, the foundation pit and surrounding buildings is monitored. The monitoring results show that the pile anchor support + high pressure jet grouting pile waterproof curtain + tube well dewatering scheme is economical and reasonable in this type of site, which ensures the safety of surrounding buildings. A reasonable process is adopted to minimize the impact on the medical conditions during the construction period.