Gray Theory is used to predict layered settlement of soft soil foundation,which reinforced by vacuum-surcharge preloading.The result shows that:Verhulst model can accurately predict layered settlement of well-distributed soil,with error of less than ten precent,but for uneven soil of foundation,the error of Verhulst model compared greatly,so the Verhulst model was modified,modified Verhulst model can accurately predict layered settlement of uneven soil of foundation.Then predict the layered settlement of foundation by different points of real datas,compared with the measured datas found that,when the settlement which out of the vacuum affected is known,Gray Model can accurately forecast the layered settlement of ground.