Using the simulation software SEEP/W of Geo-Studio and embankment stability analysis system software HH-SLOPE, the seepage stability and slope stability of different store stage of Yuiiagou tailings dam are studied. The change rules of seepage and stability of slope are researched when the elevation of the beach crest is 840 m, 875 m, 900 m and 950 m. The results show that the dry beach length, operating water level and elevation of the beach crest have certain influence on the seepage field stability of the tailing reservoir, the higher seepage gradient focused on upstream slope toe position. In different working conditions, the safety coefficient of dam slope stability is higher than the minimum safety coefficient of anti-sliding stability. It also indicates that the tailings dam is stable. The results of research provide a reasonable reference to the construction of Yujiagou tailings darn.