The pile foundation test of a high-speed bridge in Beijing is introduced as an example, including axial force, displacement monitoring design and monitoring data analysis method during test process. The pile side resistance, pile end resistance and pile foundation ultimate load of each layer of soil under the stratum conditions are obtained. Various parameters for friction pile design are also provided. Based on pile foundation test monitoring data, the numerical simulation method is used to analyze the failure load of pile foundation, evaluate the rationality of pile foundation design parameters, and optimize pile foundation design parameters such as pile length and post grouting. The mechanism of pile-soil interaction during pile foundation test is summarized, which provides reference for engineering experience for similar projects.